This article focuses on the challenges for authors of dealing with an editor’s and reviewers’ comments within the manuscript publication process. The paper commences with an overview of the peer review process. The nature and style of comments from editors and reviewers is outlined and the inherent meaning demystified. Using a wide range of anonymised examples, sample comments are categorised according to their ease of being addressed and whether or not the author agrees with them and the need to respond highlighted. Advice is offered regarding the construction of a response document, outlining how editor and reviewer comments have been addressed in the revised manuscript and an example comprising both editor and reviewer comments and author responses provided. The importance of this document in providing a clear audit trail of associated amendments to the manuscript and their justifications in response to the editor’s and reviewers’ comments is emphasised.
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